Victor Peperzak obtained his PhD at the Netherlands Cancer Institute (NKI) in Amsterdam examining the underlying mechanisms of T cell co-stimulation. He subsequently moved to the Walter and Eliza Hall Institute (WEHI) in Melbourne, Australia, as a postdoctoral fellow to study the role of pro-survival protein MCL-1 in healthy germinal center B cells and plasma cells. This research line was continued at the AMC in Amsterdam, further studying the regulation of MCL-1 in malignant B cells. He is currently a Principal Investigator at the Laboratory of Translation Immunology of the UMCU in Utrecht focusing on the development of novel drugs that target malignant B cells and multiple myeloma cells.
Regulation of (malignant) B cell survival
Personal Fellowships & Awards
MMRF research fellow award (2010-2011)
EMBO long-term fellowship (2010-2012)
ASI new investigator award (2012)
NWO-VENI (ZonMw) personal grant (2013-2016)
KWF/Alpe d’Huzes Bas Mulder Award (2015-2021)
Projects and grants
KWF/Alpe d’HuZes, Unique High Risk Project grant: nr.11270, 2017-2. Empowering the T cell killing machinery to eradicate cancer cells and prevent outgrowth (2 years, 1.0 fte technician).
KWF/Alpe d’HuZes, Research Project grant: nr.11108, 2017-1. Personalized strategy to avert drug resistance in hematologic cancers (4 years, 1.0 fte PhD student, 1.0 fte Postdoctoral fellow).
KWF/Alpe d’HuZes, Bas Mulder Award: nr.7663, 2015. Towards therapeutic targeting of Myeloid cell leukemia 1 (MCL-1) in B cell cancers (6 years, 1.0 fte technician, 0.5 fte ass. prof).
From MGUS to Multiple Myeloma, a Paradigm for Clonal Evolution of Premalignant Cells. van Nieuwenhuijzen N, Spaan I, Raymakers R, PEPERZAK V. Cancer Research 2018; 78(10): 2449-2456.
DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice. Ottina E, PEPERZAK V, Schoeler K, Carrington E, Sgonc R, Pellegrini M, Preston S, Herold M, Strasser A, Villunger A. Nature Communications 2017; 8(1): 1028.
Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling. PEPERZAK V, Slinger E, Ter Burg J, Eldering E. Cell Death Differentiation 2017;24(1):111-119.
MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL. Vikström IB, Slomp A, Carrington EM, Moesbergen LM, Chang C, Kelly GL, Glaser SP, Jansen JH, Leusen JH, Strasser A, Huang DC, Lew AM, Tarlinton DM*, PEPERZAK V*. Cell Death & Disease 2016;7(8):e2345.
Mcl-1 is essential for the survival of plasma cells. PEPERZAK V*, Vikström I*, Walker J, Glaser SP, LePage M, Coquery CM, Erickson LD, Fairfax K, Mackay F, Strasser A, Nutt SL, Tarlinton DM. Nature Immunology 2013;14(3):290-297.
Mcl-1 is essential for germinal center formation and B cell memory. Vikstrom I, Carotta S, Lüthje K, PEPERZAK V, Jost PJ, Glaser S, Busslinger M, Bouillet P, Strasser A, Nutt SL, Tarlinton DM. Science 2010;330(6007):3817-27.
ASSOCIATED TEAM MEMBERS
Laura Moesbergen (Senior technician)
Marta Cuenca (Postdoctoral fellow)
Anne Slomp (PhD student)
Ingrid Spaan (PhD student)
Laura Timmerman (Technician)
Thomas Kimman (Technician)
Sarah Grabherr (MSc student)