Confusion between the FcR gamma chain and the cytokine receptor gamma chain

 

As a scientist in the field of Fc receptors and Immunology for more than 20 years I often notice the confusion between the FcR gamma chain and the cytokine receptor gamma chain. I sometimes get requests from students for the common gamma chain, whereas the FcR gamma chain is meant, or scientist order wrong knockout mice. To end this confusion, we have written this letter to Immunity on the structure and function of cytokine receptors and signaling via the common gamma chain and compare this to the activating Fc receptors and the signaling by the Fc receptor associated gamma chain. Both gamma chains share some signaling pathways, but in sequence, function, cellular distribution, and chromosome location they diverge.

With this letter we hope we can end the confusion about the FcR gamma versus the common gamma chain, and would appreciate it very much if you could indicate the FCER1G encoded protein with Fc receptor gamma chain (FcRg) in all of your publications.