SPECIALISMS:

  • Transplantation

  • Histocompatibility

  • HLA

  • Immunology

 

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Biography

Dr. Spierings received his PhD degree as immunologist at the Leiden University Medical Center, The Netherlands and was subsequently recognized as SMBWO Immunologist by the Dutch Society for Immunology. His postdoctoral training was performed on minor H antigens in organ- and stem-cell transplantation in the laboratory of Prof. Dr. Els Goulmy, Leiden, The Netherlands. In 2008, he was appointed as lab director of the HLA laboratory of the University Medical Centre Utrecht, The Netherlands. In that position, he combines diagnostic histocompatibility testing with research. His current scientific interest focusses on the role of indirect recognition of mismatched HLA in transplantation and on post-transplant immunomonitoring via Next Generation Sequencing of T- and B-cell receptors and immunoglobulins.

Research Projects

  • Histocompatibility and transplantation
  • TCR and BCR/IG immunomonitoring

Current External Activities

  • Member of the European Federation for Immunogenetics
  • Member of the Dutch Transplant Society
  • Member of the Dutch Society for Immunology
  • HLA working party The Netherlands
  • HOVON SCT-HLA working party
  • Editorial board: Cellular Immunology, Frontiers in Immunology

Personal Fellowships & Awards

  • 2004-2007: Leukemia and Lymphoma Society, Special Fellow

  • 2016: Novartis Transplant Basic Science Award for the best basic science paper on transplantation

Scientific Publications

  • Thus KA, Ruizendaal MT, de Hoop T, Borst E, van Deutekom HW, te Boome L, Kuball J, Spierings E. Refinement of the definition of permissible HLA-DPB1 mismatches with Predicted Indirectly ReCognizable HLA-DPB1 Epitopes. Biol Blood Marrow Transplant. 2014. pii: S1083-8791(14)00393-0.

  • Dierselhuis M, Spierings E, Brand R, Hendriks M, Canossi A, Dolstra H, Eliaou JF, Enczmann J, Gervais T, Kircher B, Laurin D, Loiseau P, Sergeant R, Goulmy E. Gender influences the birth order effect in HLA-identical Stem Cell Transplantation. Blood 2013;121(23):4809-11.

  • Delemarre E, van den Broek T, Mijnheer G, Meerding J, Wehrens E, Olek S, Boes M, van Herwijnen M, Broere F, van Royen A, Wulffraat N, Prakken B, Spierings E, and Femke van Wijk F. Autologous stem cell transplantation induces functional regulatory T cell renewal and TCR diversification in experimental and human autoimmune diseases. Blood. 2016 Jan 7;127(1):91-101. 

  • Geneugelijk K, Hönger G, van Deutekom HWM, Thus KA, Keşmir C, Hösli I, Schaub S, Spierings E. Predicted Indirectly ReCognizable HLA Epitopes presented by HLA-DRB1 (PIRCHE-II) are related to HLA-antibody formation during pregnancy. Am J Transplant. 2015 Dec;15(12):3112-22. 

  • Spierings E. Minor Histocompatibility antigens: past, present, and future. Tissue Antigens. 2014; 84(4):374-60.

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Associated Team Members

  • Kirsten Geneugelijk (PhD student)

  • Wouter Fitski (Masters student, Medicine)

  • Titus de Hond (Honours student, Medicine)